Jason J. Luke, MD (Associate Professor of Medicine). Dr. Luke is Director of the UPMC HCC Cancer Immunotherapeutics Center. Dr. Luke specializes in early phase drug development for solid tumors (particularly novel immunotherapeutics and biomarkers of immunotherapy activity) as well as the management of cutaneous oncology (h-index: 37). Dr. Luke directs the Translational Immuno-Informatics Laboratory which investigates large scale informatic approaches to advance cancer immunotherapy. Dr. Luke is an active internationally recognized translational investigator leveraging work from his laboratory into more than 10 investigator-initiated, NCI CTEP and/or cooperative group clinical trials and acting as the international PI on registration intent industry studies (KEYNOTE-716). Some of these studies have changed the standard of care and are cited in the National Comprehensive Cancer Network guidelines. Dr. Luke is currently supported by a DOD award and is co-PI for the HCC UM1 NCI Phase I grant. He has received numerous awards including the Melanoma Research Foundation Humanitarian Award, Crain’s 40 under 40, Department of Defense Career Development Award, Paul Calabresi Career Development in Clinical Oncology Award (K12), ASCO Merit Award as well as Young Investigator Awards from the Melanoma Research Alliance, the Cancer Research Foundation and the Conquer Cancer Foundation of ASCO. Dr Luke has been a review panel member for the NIH R21 and DOD immunotherapy/melanoma grant review panels and has been the ASCO Scientific Committee chair for Melanoma. Dr. Luke has worked with and mentored many medical students (T35), internal medicine and pathology residents as well as oncology fellows (T32) and junior faculty medical oncology and radiation oncology faculty. His mentees have received ASCO Merit Awards and developed clinical trials from concept to trial activation and manuscript development. Dr. Luke’s trainees have been selected for the ASCO/AACR Methods in Clinical Cancer Research, SITC Sparkathon and FDA-ASCO Hematology and Oncology Fellows Workshop.